FileASSASSIN is an application that can delete any type of locked files that are on your computer. Whether the files are from a malware infection or just a particular file that will not delete - FileASSASSIN can remove it. The program uses advanced programming techniques to unload modules, close remote handles, and terminate processes to remove the particular locked file. Please use with caution as deleting critical system files may cause system errors.
http://www.malwarebytes.org/fileassassin.php